23 September 2017 Cranial nerve contrast using nerve-specific fluorophores improved by paired-agent imaging with indocyanine green as a control agent
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Abstract
Nerve preservation during surgery is critical because damage can result in significant morbidity. This remains a challenge especially for skull base surgeries where cranial nerves (CNs) are involved because visualization and access are particularly poor in that location. We present a paired-agent imaging method to enhance identification of CNs using nerve-specific fluorophores. Two myelin-targeting imaging agents were evaluated, Oxazine 4 and Rhodamine 800, and coadministered with a control agent, indocyanine green, either intravenously or topically in rats. Fluorescence imaging was performed on excised brains
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Veronica C. Torres, Victoria D. Vuong, Todd Wilson, Joshua Wewel, Richard W. Byrne, Kenneth M. Tichauer, "Cranial nerve contrast using nerve-specific fluorophores improved by paired-agent imaging with indocyanine green as a control agent," Journal of Biomedical Optics 22(9), 096012 (23 September 2017). https://doi.org/10.1117/1.JBO.22.9.096012 . Submission: Received: 12 January 2017; Accepted: 1 September 2017
Received: 12 January 2017; Accepted: 1 September 2017; Published: 23 September 2017
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