23 September 2017 Cranial nerve contrast using nerve-specific fluorophores improved by paired-agent imaging with indocyanine green as a control agent
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Abstract
Nerve preservation during surgery is critical because damage can result in significant morbidity. This remains a challenge especially for skull base surgeries where cranial nerves (CNs) are involved because visualization and access are particularly poor in that location. We present a paired-agent imaging method to enhance identification of CNs using nerve-specific fluorophores. Two myelin-targeting imaging agents were evaluated, Oxazine 4 and Rhodamine 800, and coadministered with a control agent, indocyanine green, either intravenously or topically in rats. Fluorescence imaging was performed on excised brains
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Veronica C. Torres, Veronica C. Torres, Victoria D. Vuong, Victoria D. Vuong, Todd Wilson, Todd Wilson, Joshua Wewel, Joshua Wewel, Richard W. Byrne, Richard W. Byrne, Kenneth M. Tichauer, Kenneth M. Tichauer, } "Cranial nerve contrast using nerve-specific fluorophores improved by paired-agent imaging with indocyanine green as a control agent," Journal of Biomedical Optics 22(9), 096012 (23 September 2017). https://doi.org/10.1117/1.JBO.22.9.096012 . Submission: Received: 12 January 2017; Accepted: 1 September 2017
Received: 12 January 2017; Accepted: 1 September 2017; Published: 23 September 2017
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