Flexible nine-channel photodetector probe facilitated intraspinal multisite transcutaneous photobiomodulation therapy dosimetry in cadaver dogs

Daqing Piao; Lara A. Sypniewski D.V.M.; Christian Bailey; Danielle Dugat D.V.M.; Daniel J. Burba; Luis H. De Taboada

doi:10.1117/1.JBO.23.1.010503

23 January 2018 Flexible nine-channel photodetector probe facilitated intraspinal multisite transcutaneous photobiomodulation therapy dosimetry in cadaver dogs

Daqing Piao, Lara A. Sypniewski D.V.M., Christian Bailey, Danielle Dugat D.V.M., Daniel J. Burba, Luis H. De Taboada

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Journal of Biomedical Optics, Vol. 23, Issue 1, 010503 (January 2018). https://doi.org/10.1117/1.JBO.23.1.010503

Abstract

Noninvasive photobiomodulation therapy (PBMT) of spinal cord disease remains speculative due to the lack of evidence for whether photobiomodulatory irradiances can be transcutaneously delivered to the spinal cord under a clinically acceptable PBMT surface irradiation protocol. We developed a flexible nine-channel photodetection probe for deployment within the spinal canal of a cadaver dog after hemilaminectomy to measure transcutaneously transmitted PBMT irradiance at nine sites over an eight-cm spinal canal length. The probe was built upon a 6.325-mm tubular stem, to the surface of which nine photodiodes were epoxied at approximately 1 cm apart. The photodiode has a form factor of 4.80 mm×2.10 mm×1.15 mm (length×width×height). Each photodiode was individually calibrated to deliver 1 V per 7.58 μW/cm2 continuous irradiance at 850 nm. The outputs of eight photodiodes were logged concurrently using a data acquisition module interfacing eight channels of differential analog signals, while the output of the ninth photodiode was measured by a precision multimeter. This flexible probe rendered simultaneous intraspinal (nine-site) measurements of transcutaneous PBMT irradiations at 980 nm in a pilot cadaver dog model. At a surface continuous irradiance of 3.14 W/cm2 applied off-contact between L1 and L2, intraspinal irradiances picked up by nine photodiodes had a maximum of 327.48 μW/cm2 without the skin and 5.68 μW/cm2 with the skin.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Daqing Piao, Lara A. Sypniewski D.V.M., Christian Bailey, Danielle Dugat D.V.M., Daniel J. Burba, and Luis H. De Taboada "Flexible nine-channel photodetector probe facilitated intraspinal multisite transcutaneous photobiomodulation therapy dosimetry in cadaver dogs," Journal of Biomedical Optics 23(1), 010503 (23 January 2018). https://doi.org/10.1117/1.JBO.23.1.010503

Received: 2 November 2017; Accepted: 28 December 2017; Published: 23 January 2018

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