Photoacoustic tomography (PAT) is a hybrid imaging modality where we intend to reconstruct optical properties of heterogeneous media from measured ultrasound signals generated by the photoacoustic effect. In recent years, there have been considerable interests in using PAT to image two-photon absorption, in addition to the usual single-photon absorption, inside diffusive media. We present a mathematical model for quantitative image reconstruction in two-photon photoacoustic tomography (TP-PAT). We propose a computational strategy for the reconstruction of the optical absorption coefficients and provide some numerical evidences based on synthetic photoacoustic acoustic data to demonstrate the feasibility of quantitative reconstructions in TP-PAT.
"Quantitative photoacoustic imaging of two-photon absorption," Journal of Biomedical Optics 23(1), 016002 (2 January 2018). https://doi.org/10.1117/1.JBO.23.1.016002
. Submission: Received: 5 July 2017; Accepted: 5 December 2017
Received: 5 July 2017; Accepted: 5 December 2017; Published: 2 January 2018