14 February 2018 Lens implementation on the GATE Monte Carlo toolkit for optical imaging simulation
Author Affiliations +
Abstract
Optical imaging techniques are widely used for in vivo preclinical studies, and it is well known that the Geant4 Application for Emission Tomography (GATE) can be employed for the Monte Carlo (MC) modeling of light transport inside heterogeneous tissues. However, the GATE MC toolkit is limited in that it does not yet include optical lens implementation, even though this is required for a more realistic optical imaging simulation. We describe our implementation of a biconvex lens into the GATE MC toolkit to improve both the sensitivity and spatial resolution for optical imaging simulation. The lens implemented into the GATE was validated against the ZEMAX optical simulation using an US air force 1951 resolution target. The ray diagrams and the charge-coupled device images of the GATE optical simulation agreed with the ZEMAX optical simulation results. In conclusion, the use of a lens on the GATE optical simulation could improve the image quality of bioluminescence and fluorescence significantly as compared with pinhole optics.
© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)
Han Gyu Kang, Han Gyu Kang, Swong Hyun Song, Swong Hyun Song, Young Been Han, Young Been Han, Kyeong Min Kim, Kyeong Min Kim, Seong Jong Hong, Seong Jong Hong, } "Lens implementation on the GATE Monte Carlo toolkit for optical imaging simulation," Journal of Biomedical Optics 23(2), 026003 (14 February 2018). https://doi.org/10.1117/1.JBO.23.2.026003 . Submission: Received: 17 September 2017; Accepted: 22 January 2018
Received: 17 September 2017; Accepted: 22 January 2018; Published: 14 February 2018
JOURNAL ARTICLE
13 PAGES


SHARE
Back to Top