28 March 2018 High-sensitivity terahertz imaging of traumatic brain injury in a rat model
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We demonstrated that different degrees of experimental traumatic brain injury (TBI) can be differentiated clearly in fresh slices of rat brain tissues using transmission-type terahertz (THz) imaging system. The high absorption region in THz images corresponded well with the injured area in visible images and magnetic resonance imaging results. The THz image and absorption characteristics of dehydrated paraffin-embedded brain slices and the hematoxylin and eosin (H&E)-stained microscopic images were investigated to account for the intrinsic differences in the THz images for the brain tissues suffered from different degrees of TBI and normal tissue aside from water. The THz absorption coefficients of rat brain tissues showed an increase in the aggravation of brain damage, particularly in the high-frequency range, whereas the cell density decreased as the order of mild, moderate, and severe TBI tissues compared with the normal tissue. Our results indicated that the different degrees of TBI were distinguishable owing to the different water contents and probable hematoma components distribution rather than intrinsic cell intensity. These promising results suggest that THz imaging has great potential as an alternative method for the fast diagnosis of TBI.
© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)
Hengli Zhao, Hengli Zhao, Yuye Wang, Yuye Wang, Linyu Chen, Linyu Chen, Jia Shi, Jia Shi, Kang Ma, Kang Ma, Longhuang Tang, Longhuang Tang, Degang Xu, Degang Xu, Jianquan Yao, Jianquan Yao, Hua Feng, Hua Feng, Tunan Chen, Tunan Chen, } "High-sensitivity terahertz imaging of traumatic brain injury in a rat model," Journal of Biomedical Optics 23(3), 036015 (28 March 2018). https://doi.org/10.1117/1.JBO.23.3.036015 . Submission: Received: 6 November 2017; Accepted: 9 March 2018
Received: 6 November 2017; Accepted: 9 March 2018; Published: 28 March 2018

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