13 April 2018 Diagnosis of oral lichen planus from analysis of saliva samples using terahertz time-domain spectroscopy and chemometrics
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Abstract
The ability to diagnose oral lichen planus (OLP) based on saliva analysis using THz time-domain spectroscopy and chemometrics is discussed. The study involved 30 patients (2 male and 28 female) with OLP. This group consisted of two subgroups with the erosive form of OLP (n  =  15) and with the reticular and papular forms of OLP (n  =  15). The control group consisted of six healthy volunteers (one male and five females) without inflammation in the mucous membrane in the oral cavity and without periodontitis. Principal component analysis was used to reveal informative features in the experimental data. The one-versus-one multiclass classifier using support vector machine binary classifiers was used. The two-stage classification approach using several absorption spectra scans for an individual saliva sample provided 100% accuracy of differential classification between OLP subgroups and control group.
© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)
Yury V. Kistenev, Alexey V. Borisov, Maria A. Titarenko, Olga D. Baydik, Alexander V. Shapovalov, "Diagnosis of oral lichen planus from analysis of saliva samples using terahertz time-domain spectroscopy and chemometrics," Journal of Biomedical Optics 23(4), 045001 (13 April 2018). https://doi.org/10.1117/1.JBO.23.4.045001 Submission: Received 31 December 2017; Accepted 28 March 2018
Submission: Received 31 December 2017; Accepted 28 March 2018
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