9 April 2018 Pancreatic cancer cell detection by targeted lipid microbubbles and multiphoton imaging
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Abstract
Surgical resection of pancreatic cancer represents the only chance of cure and long-term survival in this common disease. Unfortunately, determination of a cancer-free margin at surgery is based on one or two tiny frozen section biopsies, which is far from ideal. Not surprisingly, cancer is usually left behind and is responsible for metastatic disease. We demonstrate a method of receptor-targeted imaging using peptide ligands, lipid microbubbles, and multiphoton microscopy that could lead to a fast and accurate way of examining the entire cut surface during surgery. Using a plectin-targeted microbubble, we performed a blinded in-vitro study to demonstrate avid binding of targeted microbubbles to pancreatic cancer cells but not noncancerous cell lines. Further work should lead to a much-needed point-of-care diagnostic test for determining clean margins in oncologic surgery.
© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)
Benjamin Cromey, Benjamin Cromey, Ashley McDaniel, Ashley McDaniel, Terry Matsunaga, Terry Matsunaga, Josef Vagner, Josef Vagner, Khanh Quoc Kieu, Khanh Quoc Kieu, Bhaskar Banerjee, Bhaskar Banerjee, } "Pancreatic cancer cell detection by targeted lipid microbubbles and multiphoton imaging," Journal of Biomedical Optics 23(4), 046501 (9 April 2018). https://doi.org/10.1117/1.JBO.23.4.046501 . Submission: Received: 19 December 2017; Accepted: 13 March 2018
Received: 19 December 2017; Accepted: 13 March 2018; Published: 9 April 2018
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