11 May 2018 In vivo super-resolution imaging of transient retinal phototropism evoked by oblique light stimulation
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Abstract
Rod-dominated transient retinal phototropism (TRP) has been observed in freshly isolated retinas, promising a noninvasive biomarker for objective assessment of retinal physiology. However, in vivo mapping of TRP is challenging due to its subcellular signal magnitude and fast time course. We report here a virtually structured detection-based super-resolution ophthalmoscope to achieve subcellular spatial resolution and millisecond temporal resolution for in vivo imaging of TRP. Spatiotemporal properties of in vivo TRP were characterized corresponding to variable light intensity stimuli, confirming that TRP is tightly correlated with early stages of phototransduction.
© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)
Yiming Lu, Changgeng Liu, Xincheng Yao, "In vivo super-resolution imaging of transient retinal phototropism evoked by oblique light stimulation," Journal of Biomedical Optics 23(5), 050502 (11 May 2018). https://doi.org/10.1117/1.JBO.23.5.050502 Submission: Received 15 March 2018; Accepted 19 April 2018
Submission: Received 15 March 2018; Accepted 19 April 2018
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