15 May 2018 Test–retest reliability of brain mitochondrial cytochrome-c-oxidase assessed by functional near-infrared spectroscopy
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Abstract
Functional near-infrared spectroscopy (fNIRS) is a noninvasive method for measuring in vivo both hemodynamic and mitochondrial metabolic activities in brain cortical structures. Although the test–retest reliability of the hemodynamic measures, such as reflected by oxygenated (HbO2), deoxygenated (HHb) hemoglobin, and the tissue oxygenation index (TOI), has been previously reported to be good to excellent, the reliability of the metabolic signal indexed by oxidized cytochrome-c-oxidase (oxCCO) has not been reported. The present test–retest study compared the reliability of the metabolic and hemodynamic signals in 10 healthy participants undergoing hypo- and hypercapnia challenges. The primary reliability measure was the intraclass correlation coefficient (ICC). Results of both hypo- and hypercapnia showed that the oxCCO signal (ICC  =  0.876  /  0.757) had robust reliability comparable with that of the HbO2 (ICC  =  0.841  /  0.801), HHb (ICC  =  0.804  /  0.571), and TOI (ICC  =  0.574  /  0.614) signals. These findings show that the oxCCO signal can be assessed by fNIRS with comparable reliability to the hemodynamic measures. We discuss the results in light of current interest in a mitochondrial metabolic marker derived from fNIRS.
© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)
Lisa Holper, J. John Mann, "Test–retest reliability of brain mitochondrial cytochrome-c-oxidase assessed by functional near-infrared spectroscopy," Journal of Biomedical Optics 23(5), 056006 (15 May 2018). https://doi.org/10.1117/1.JBO.23.5.056006 Submission: Received 8 December 2017; Accepted 24 April 2018
Submission: Received 8 December 2017; Accepted 24 April 2018
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