Multifunctional biomedical applications of magnetic nanodiamond

Elena Perevedentseva; Artashes Karmenyan; Yu-Chung Lin; Chang-You Song; Zhe-Rui Lin; Ashek-I Ahmed; Chia-Chi Chang; Svetlana B. Norina; Valentina Bessalova; Nikolai Perov; Olga Levinson; Boris Zousman; Chia-Liang Cheng

doi:10.1117/1.JBO.23.9.091404

21 March 2018 Multifunctional biomedical applications of magnetic nanodiamond

Elena Perevedentseva; Artashes Karmenyan; Yu-Chung Lin; Chang-You Song; Zhe-Rui Lin; Ashek-I Ahmed; Chia-Chi Chang; Svetlana B. Norina; Valentina Bessalova; Nikolai Perov; Olga Levinson; Boris Zousman; Chia-Liang Cheng

Author Affiliations +

J. of Biomedical Optics, 23(9), 091404 (2018). https://doi.org/10.1117/1.JBO.23.9.091404

Abstract

The research and development for biomedical applications are recently focused on multifunctional nanoparticles. To integrate various functionalities, different methods of modifying the particle’s physical properties are developed. Among the considered, nanodiamond (ND) is a promising candidate for the development of multifunctional complex due to its variable features in size, structure, surface chemistry, physical properties, and biocompatibility. In addition to its well-studied structural, surface, electrochemical and photonic properties, strong magnetism of ND can be observed. In the present work, magnetically modified ND is introduced in terms of its bioapplications. Along with the soft ferromagnetism of ND, the increased fluorescence at one- and two-photon excitation is realized. Utilizing the combined magnetic and fluorescence properties of the magnetically modified ND, fluorescence imaging, fluorescence lifetime imaging and manipulation of cells by magnetic field are demonstrated. The perspectives to use the magnetic ND for drug delivery, cells magnetic separation and filtration, in bioengineering to control the cell distribution combined with imaging and treatment are discussed.

Citation Download Citation

Elena Perevedentseva, Elena Perevedentseva, Artashes Karmenyan, Artashes Karmenyan, Yu-Chung Lin, Yu-Chung Lin, Chang-You Song, Chang-You Song, Zhe-Rui Lin, Zhe-Rui Lin, Ashek-I Ahmed, Ashek-I Ahmed, Chia-Chi Chang, Chia-Chi Chang, Svetlana B. Norina, Svetlana B. Norina, Valentina Bessalova, Valentina Bessalova, Nikolai Perov, Nikolai Perov, Olga Levinson, Olga Levinson, Boris Zousman, Boris Zousman, Chia-Liang Cheng, Chia-Liang Cheng, } "Multifunctional biomedical applications of magnetic nanodiamond," Journal of Biomedical Optics 23(9), 091404 (21 March 2018). https://doi.org/10.1117/1.JBO.23.9.091404 . Submission: Received: 13 December 2017; Accepted: 26 February 2018

Received: 13 December 2017; Accepted: 26 February 2018; Published: 21 March 2018

ACCESS THE FULL ARTICLE

PERSONAL SIGN IN
Full access may be available with your subscription

Email or Username Forgot your username?

Password Forgot your password?

Show

Remember Email/Username on this computer

Remember Password

No SPIE account? Create an account
or Institutional Sign In via Shibboleth

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $20.00

Non-members: $25.00 ADD TO CART

Show All Keywords

Keywords/Phrases

Search In:

Publication Years