22 October 2018 Compact ultrasound-guided diffuse optical tomography system for breast cancer imaging
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Abstract
Near-infrared diffuse optical tomography (DOT) has demonstrated a great potential as an adjunct modality for differentiation of malignant and benign breast lesions and for monitoring treatment response in patients with locally advanced breast cancers. The path toward commercialization of DOT techniques depends upon the improvement of robustness and user-friendliness of this technique in hardware and software. In this study, we introduce our recently developed ultrasound-guided DOT system, which has been improved in system compactness, robustness, and user-friendliness by custom-designed electronics, automated data preprocessing, and implementation of a new two-step reconstruction algorithm. The system performance has been tested with several sets of solid and blood phantoms and the results show accuracy in reconstructed absorption coefficients as well as blood oxygen saturation. A clinical example of a breast cancer patient, who was undergoing neoadjuvant chemotherapy, is given to demonstrate the system performance.
© 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)
Hamed Vavadi, Hamed Vavadi, Atahar Mostafa, Atahar Mostafa, Feifei Zhou, Feifei Zhou, K. M. Shihab Uddin, K. M. Shihab Uddin, Murad Althobaiti, Murad Althobaiti, Chen Xu, Chen Xu, Rajeev Bansal, Rajeev Bansal, Foluso Ademuyiwa, Foluso Ademuyiwa, Steven Poplack, Steven Poplack, Quing Zhu, Quing Zhu, "Compact ultrasound-guided diffuse optical tomography system for breast cancer imaging," Journal of Biomedical Optics 24(2), 021203 (22 October 2018). https://doi.org/10.1117/1.JBO.24.2.021203 . Submission: Received: 13 March 2018; Accepted: 19 September 2018
Received: 13 March 2018; Accepted: 19 September 2018; Published: 22 October 2018
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