In this article, a simple color correction method for the color reproduction of image obtained by angioscope is reported. We present the method to obtain the matrices theoretically and experimentally, respectively. For the angioscope system, we suggest two matrices: an average color correction matrix A and a blood vessel color correction matrix A'. Using the two matrices, the images of several color samples captured by an angioscope are processed, and their reproduced colors are evaluated. With this method, the discrimination ability of the angioscope will be improved dramatically.