1 July 1999 Topical versus systemic 5-aminolevulinic acid administration for photodynamic therapy of the colon in B10.RBP mice
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Abstract
5-aminolevulinic acid (5-ALA) is an interesting photosensitizing substance for photodynamic therapy (PDT), successfully applied topically for urological malignancy. In gastroenetrology it has proven efficacy for treatment of some GI neoplasms after systemic administration. This study was aimed at investigating the possibility of topical 5-ALA administration also for the PDT of gut cancer in a mice model. 5-ALA solution at different concentrations (5%, 1.5%, and 0.5%) was instilled in the colon of mice, which was later removed and examined by fluorescence microscopy. The results of fluorescence studies were compared with those obtained in a control group treated with 5-ALA given systemically. Satisfactory epithelial fluorescence levels and good selectivity between gut layers was obtained after intracolonic 5-ALA instillation. However, mean fluorescence intensity was higher after systemic drug application. Our results suggest that 5-ALA may probably be used topically for the PDT of some gut neoplasms.
Maciej Gil, Maciej Gil, Marek Woszczynski, Marek Woszczynski, Jaroslaw Regula, Jaroslaw Regula, Alexander J. MacRobert, Alexander J. MacRobert, Eugeniusz Butruk, Eugeniusz Butruk, Stephen G. Bown, Stephen G. Bown, } "Topical versus systemic 5-aminolevulinic acid administration for photodynamic therapy of the colon in B10.RBP mice," Journal of Biomedical Optics 4(3), (1 July 1999). https://doi.org/10.1117/1.429929 . Submission:
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