1 October 1999 Optical analysis of cirrhotic liver by near infrared time resolved spectroscopy
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Abstract
The severity of liver cirrhosis was related with the optical properties of liver tissue. Various grades of liver cirrhosis were produced in rats by intraperitoneal injection of thioacetamide (TAA) for different periods: 4 weeks, 8 weeks, 12 weeks, and 16 weeks. Optical properties of the liver, absorption coefficient (µa) and scattering coefficient (µs'), were measured by near-infrared time-resolved spectroscopy. Histological examination confirmed cirrhotic changes in the liver, which were more severe in rats with TAA administration for longer periods. The ma increased in 4- and 8-week rats, and then decreased in 12- and 16-week rats. The µa of blood-free liver decreased as liver cirrhosis progressed. The hemoglobin content in the liver calculated from the µa values increased in 4- and 8-week rats and decreased in 12- and 16-week rats. The µs' decreased in the cirrhotic liver, probably reflecting the decrease in the mitochondria content. It was shown that µa and µs' determination is useful to assess the severity of liver cirrhosis.
Toshihiro Nishio, Toshihiro Nishio, Toshiyuki Kitai, Toshiyuki Kitai, Mitsuharu Miwa, Mitsuharu Miwa, Rei Takahashi, Rei Takahashi, Yoshio Yamaoka, Yoshio Yamaoka, } "Optical analysis of cirrhotic liver by near infrared time resolved spectroscopy," Journal of Biomedical Optics 4(4), (1 October 1999). https://doi.org/10.1117/1.429941 . Submission:
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