1 January 2000 Activation of visual cortex imaged by 24 channel near-infrared spectroscopy
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Near-infrared spectroscopy (NIRS) is a noninvasive technique for continuous monitoring of the amounts of total hemoglobin (total-Hb), oxygenated hemoglobin, (oxy-Hb) and deoxygenated hemoglobin (deoxy-Hb). The purpose of the present study was to demonstrate the utility of NIRS in functional imaging of the human visual cortex. A new NIRS imaging system enabled measurements from 24 scalp locations covering a 9 cm sq area. Topographic images were obtained from interpolations of the concentration changes between measurement points. Five healthy subjects between 25 and 49 years of age were investigated. After a resting baseline period of 50 s, the subjects were exposed to a visual stimulus for 20 s, followed by a 50 s resting period in a dimly lit, sound attenuating room. The visual stimulus was a circular, black and white, alternating checkerboard. In four of five subjects the visual cortex was the most activated area during visual stimulation. This is the first reported use of a NIRSimaging system for assessing hemodynamic changes in the human visual cortex. The typical hemodynamic changes expected were observed; the total-Hb and oxy-Hb increased just after the start of stimulation and plateaued after 10 s of the stimulation period.
Kazumi Takahashi, Kazumi Takahashi, S. Ogata, S. Ogata, R. Yamamoto, R. Yamamoto, S. Shiotsuka, S. Shiotsuka, Atsushi Maki, Atsushi Maki, Yuichi Yamashita, Yuichi Yamashita, Tsuyoshi Yamamoto, Tsuyoshi Yamamoto, Hideaki Koizumi, Hideaki Koizumi, H. Hirasawa, H. Hirasawa, M. Igawa, M. Igawa, Y. Atsumi, Y. Atsumi, } "Activation of visual cortex imaged by 24 channel near-infrared spectroscopy," Journal of Biomedical Optics 5(1), (1 January 2000). https://doi.org/10.1117/1.429973 . Submission:

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