1 July 2000 Antibody-based biosensor for breast cancer with ultrasonic regeneration
Author Affiliations +
J. of Biomedical Optics, 5(3), (2000). doi:10.1117/1.430006
Abstract
We describe a novel method and instrumental setup for regenerating antibodies immobilized on a fiberoptic probe of an immunosensor using ultrasonic irradiation with broadband imaging transducers. The instrumental setup and irradiation conditions for antibody regeneration using ultrasound are described. The results of the measurements with antibody against breast cancer antigen illustrate the effectiveness and potential of the regenerable immunosensor. A 65% removal of the antigens bound to the Mab immobilized on the fiber surface is attained after ultrasound regeneration.
Maria C. Moreno-Bondi, Joel Mobley, Jean Pierre Alarie, Tuan Vo-Dinh, "Antibody-based biosensor for breast cancer with ultrasonic regeneration," Journal of Biomedical Optics 5(3), (1 July 2000). http://dx.doi.org/10.1117/1.430006
JOURNAL ARTICLE
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KEYWORDS
Ultrasonics

Ultrasonography

Transducers

Biosensors

Breast cancer

Optical fibers

Cavitation

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