1 April 2001 Near-infrared fluorescent dyes for enhanced contrast in optical mammography: phantom experiments
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Abstract
Optical mammography with near-infrared (NIR) light using time-domain, frequency-domain, or continuous-wave techniques is a novel imaging modality to locate human breast tumors. By investigating excised specimens of normal and diseased mamma tissue we were able to demonstrate that differences in their scattering properties are a poor predictive parameter for normal and diseased mamma tissue. This paper describes the application of a NIR dye to improve the differentiation between breast tumors and normal tissue in a rat model. The NIR dye furnished a high tumor-to-tissue contrast ratio (6:1) in fluorescence images. Furthermore, this dye was used to develop liquid scattering phantoms with absorbing and fluorescent inhomogeneities. Using frequency-domain and time-domain instrumentation these inhomogeneities were localized at sufficient contrast by their increased absorption and fluorescence. Contrast between inhomogeneities and surrounding medium could be improved by combining fluorescence and transmittance images.
© (2001) Society of Photo-Optical Instrumentation Engineers (SPIE)
Bernd Ebert, Uwe Sukowski, Dirk Grosenick, Heidrun Wabnitz, K. Thomas Moesta, Kai Licha, Andreas Becker, Wolfhard Semmler, Peter M. Schlag, Herbert H. Rinneberg, "Near-infrared fluorescent dyes for enhanced contrast in optical mammography: phantom experiments," Journal of Biomedical Optics 6(2), (1 April 2001). https://doi.org/10.1117/1.1350561 . Submission:
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