1 April 2001 Near-infrared fluorescent dyes for enhanced contrast in optical mammography: phantom experiments
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Optical mammography with near-infrared (NIR) light using time-domain, frequency-domain, or continuous-wave techniques is a novel imaging modality to locate human breast tumors. By investigating excised specimens of normal and diseased mamma tissue we were able to demonstrate that differences in their scattering properties are a poor predictive parameter for normal and diseased mamma tissue. This paper describes the application of a NIR dye to improve the differentiation between breast tumors and normal tissue in a rat model. The NIR dye furnished a high tumor-to-tissue contrast ratio (6:1) in fluorescence images. Furthermore, this dye was used to develop liquid scattering phantoms with absorbing and fluorescent inhomogeneities. Using frequency-domain and time-domain instrumentation these inhomogeneities were localized at sufficient contrast by their increased absorption and fluorescence. Contrast between inhomogeneities and surrounding medium could be improved by combining fluorescence and transmittance images.
© (2001) Society of Photo-Optical Instrumentation Engineers (SPIE)
Bernd Ebert, Bernd Ebert, Uwe Sukowski, Uwe Sukowski, Dirk Grosenick, Dirk Grosenick, Heidrun Wabnitz, Heidrun Wabnitz, K. Thomas Moesta, K. Thomas Moesta, Kai Licha, Kai Licha, Andreas Becker, Andreas Becker, Wolfhard Semmler, Wolfhard Semmler, Peter M. Schlag, Peter M. Schlag, Herbert H. Rinneberg, Herbert H. Rinneberg, } "Near-infrared fluorescent dyes for enhanced contrast in optical mammography: phantom experiments," Journal of Biomedical Optics 6(2), (1 April 2001). https://doi.org/10.1117/1.1350561 . Submission:

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