1 July 2001 Study of the mechanism of a chemotherapeutic drug in living cancer cells by two-photon laser scanning microspectrofluorometry
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Abstract
In this study, we present a spectroscopic study of the entry pattern of a chemotherapeutic drug (AN-152) and its carrier hormone ([D-Lys6]LH-RH) into living cancer cells, with the help of our twophoton probes and a home-built localized microspectrofluorometer coupled with two photon laser scanning microscope (TPLSM). Due to the inherent localization ability of TPLSM, we were able to identify the drug and carrier location in different compartments of the cancer cells in vitro. The apparent doxorubicin-assisted nucleic accumulation of AN-152 suggests a possible nuclear action of the drug on cell proliferation.
© (2001) Society of Photo-Optical Instrumentation Engineers (SPIE)
Xiaopeng Wang, Haridas E. Pudavar, Rakesh Kapoor, Linda J. Krebs, Earl J. Bergey, Charles Liebow, Paras N. Prasad, Attila Nagy, Andrew V. Schally, "Study of the mechanism of a chemotherapeutic drug in living cancer cells by two-photon laser scanning microspectrofluorometry," Journal of Biomedical Optics 6(3), (1 July 2001). https://doi.org/10.1117/1.1385511 . Submission:
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