1 January 2002 Laser activated fluorescence measurements and morphological features: an in vivo study of clearance time of FITC tagged cell markers
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Abstract
Fourteen BALB/c mice were divided into two groups. One group served as the control and the second group was injected with a squamous cell carcinoma cell line to the tongue. After tumor development (1–4 weeks), mice were injected with a FITC conjugated CD3 marker to their tongues. Immediately after the marker injection, the clearance of the marker was measured using a laser spectroscopy system. The markers were excited by an argon laser at 488 nm and the fluorescence signal was measured as a function of time. A biopsy was taken from every mouse after the procedure and the excised tissue was histologically evaluated. Analysis of clearance times revealed a second order exponential decay for both groups with a slower pace of signal clearance for the sick mice.
© (2002) Society of Photo-Optical Instrumentation Engineers (SPIE)
Israel Gannot, Israel Gannot, Gallya Gannot, Gallya Gannot, A. Garashi, A. Garashi, Amir H. Gandjbakhche, Amir H. Gandjbakhche, A. Buchner, A. Buchner, Yona Keisari, Yona Keisari, } "Laser activated fluorescence measurements and morphological features: an in vivo study of clearance time of FITC tagged cell markers," Journal of Biomedical Optics 7(1), (1 January 2002). https://doi.org/10.1117/1.1427913 . Submission:
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