1 July 2003 In vivo endoscopic tissue diagnostics based on spectroscopic absorption, scattering, and phase function properties
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J. of Biomedical Optics, 8(3), (2003). doi:10.1117/1.1578494
Abstract
A fast spectroscopic system for superficial and local determination of the absorption and scattering properties of tissue (480 to 950 nm) is described. The probe can be used in the working channel of an endoscope. The scattering properties include the reduced scattering coefficient and a parameter of the phase function called γ, which depends on its first two moments. The inverse problem algorithm is based on the fit of absolute reflectance measurements to cubic B-spline functions derived from the interpolation of a set of Monte Carlo simulations. The algorithm's robustness was tested with simulations altered with various amounts of noise. The method was also assessed on tissue phantoms of known optical properties. Finally, clinical measurements performed endoscopically in vivo in the stomach of human subjects are presented. The absorption and scattering properties were found to be significantly different in the antrum and in the fundus and are correlated with histopathologic observations. The method and the instrument show promise for noninvasive tissue diagnostics of various epithelia.
Philippe Thueler, Igor Charvet, Frédéric P. Bevilacqua, Michel Saint Ghislain, G. Ory, Pierre Marquet, Paolo Meda, Ben Vermeulen, Christian D. Depeursinge, "In vivo endoscopic tissue diagnostics based on spectroscopic absorption, scattering, and phase function properties," Journal of Biomedical Optics 8(3), (1 July 2003). http://dx.doi.org/10.1117/1.1578494
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KEYWORDS
Reflectivity

Tissue optics

Tissues

Monte Carlo methods

Absorption

Scattering

In vivo imaging

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