1 January 2004 Determination of burn depth by polarization-sensitive optical coherence tomography
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J. of Biomedical Optics, 9(1), (2004). doi:10.1117/1.1629680
An assessment of burn depth is a key step in guiding the treatment of patients who have sustained thermal injuries. Polarization-sensitive optical coherence tomography (PS-OCT) might eventually provide the physician with a quantitative estimate of actual burn depth. Burns of various depths were induced by contacting rat skin with a brass rod preheated to 75 °C for 5, 15, or 30 s. Thermal injury denatured the collagen in the skin, and PS-OCT imaged the resulting reduction of birefringence through the depth-resolved changes in the polarization state of light propagated and reflected from the sample. Stokes vectors were calculated for each point in the PS-OCT images and the reduction in the rate of phase retardation between two orthogonal polarizations of light (deg/µm) was found to show a consistent trend with burn exposure time. PS-OCT is a noninvasive technique with potential to give the physician the information needed to formulate an optimal treatment plan for burn patients.
Shyam M. Srinivas, Johannes F. de Boer, Boris Hyle Park, Kourosh Keikhanzadeh, Huai-En L. Huang, Jun Zhang, Woong Gyu Jung, Zhongping Chen, John Stuart Nelson, "Determination of burn depth by polarization-sensitive optical coherence tomography," Journal of Biomedical Optics 9(1), (1 January 2004). https://doi.org/10.1117/1.1629680

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