1 January 2004 Determination of burn depth by polarization-sensitive optical coherence tomography
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An assessment of burn depth is a key step in guiding the treatment of patients who have sustained thermal injuries. Polarization-sensitive optical coherence tomography (PS-OCT) might eventually provide the physician with a quantitative estimate of actual burn depth. Burns of various depths were induced by contacting rat skin with a brass rod preheated to 75 °C for 5, 15, or 30 s. Thermal injury denatured the collagen in the skin, and PS-OCT imaged the resulting reduction of birefringence through the depth-resolved changes in the polarization state of light propagated and reflected from the sample. Stokes vectors were calculated for each point in the PS-OCT images and the reduction in the rate of phase retardation between two orthogonal polarizations of light (deg/µm) was found to show a consistent trend with burn exposure time. PS-OCT is a noninvasive technique with potential to give the physician the information needed to formulate an optimal treatment plan for burn patients.
© (2004) Society of Photo-Optical Instrumentation Engineers (SPIE)
Shyam M. Srinivas, Shyam M. Srinivas, Johannes F. de Boer, Johannes F. de Boer, Boris Hyle Park, Boris Hyle Park, Kourosh Keikhanzadeh, Kourosh Keikhanzadeh, Huai-En L. Huang, Huai-En L. Huang, Jun Zhang, Jun Zhang, Woong Gyu Jung, Woong Gyu Jung, Zhongping Chen, Zhongping Chen, John Stuart Nelson, John Stuart Nelson, } "Determination of burn depth by polarization-sensitive optical coherence tomography," Journal of Biomedical Optics 9(1), (1 January 2004). https://doi.org/10.1117/1.1629680 . Submission:

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