1 March 2004 Metabolic imaging of tissues by infrared fiber-optic spectroscopy: an efficient tool for medical diagnosis
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Abstract
Infrared fingerprints of molecules in biology contain much information on cells metabolism allowing one to distinguish between healthy and altered tissues. Here, to collect infrared signatures, we used evanescent wave spectroscopy based on an original infrared transmitting tapered glass fiber. A strict control of the fiber diameter in the tapered sensing zone allows high sensitivity and wide spectral range exploration from 800 to 3000 cm–1. Then, merely in depositing the mouse liver biopsies on the fiber, this device has enable us to differentiate between tumorous and healthy tissues.
© (2004) Society of Photo-Optical Instrumentation Engineers (SPIE)
Sandrine Hocde, Sandrine Hocde, Olivier Loréal, Olivier Loréal, Olivier Sire, Olivier Sire, Catherine Boussard-Pledel, Catherine Boussard-Pledel, Bruno Bureau, Bruno Bureau, B. Turlin, B. Turlin, Julie Keirsse, Julie Keirsse, P. Leroyer, P. Leroyer, Jacques Lucas, Jacques Lucas, } "Metabolic imaging of tissues by infrared fiber-optic spectroscopy: an efficient tool for medical diagnosis," Journal of Biomedical Optics 9(2), (1 March 2004). https://doi.org/10.1117/1.1646415 . Submission:
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