1 March 2004 Use of optical coherence tomography to monitor biological tissue freezing during cryosurgery
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Abstract
The use of optical coherence tomography (OCT) for imaging skin during cryosurgery is evaluated. OCT provides high spatial resolution (5–10 µm) images of optical backscattering due to local variations in refractive index, such as the boundary between liquid and frozen water in tissue. Time resolved OCT images were acquired during freezing of water, IntralipidTM, and in vivo hamster skin. Subsurface morphological changes were evident only during freezing of Intralipid and skin. A simple thermal model was applied which predicted freezing times on the same order of magnitude as those observed in OCT images. OCT can be used as a feedback tool during cryosurgical procedures to monitor progression of the freezing front.
© (2004) Society of Photo-Optical Instrumentation Engineers (SPIE)
Bernard Choi, Thomas E. Milner, Jeehyun Kim, Jared N. Goodman, Gracie Vargas, Guillermo Aguilar, John Stuart Nelson, "Use of optical coherence tomography to monitor biological tissue freezing during cryosurgery," Journal of Biomedical Optics 9(2), (1 March 2004). https://doi.org/10.1117/1.1648647 . Submission:
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