1 May 2004 Online monitoring of urea concentration in dialysate with dual-beam Fourier-transform near-infrared spectroscopy
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Abstract
The robustness of a dual-beam, optical null, Fourier-transform near-infrared (FTNIR) spectrometer was investigated by means of online, near-infrared measurements and predictions of urea concentrations in spent dialysate during hemodialysis treatment. Simple multivariate calibration using a few factors based on a small number of prepared samples provided stable and accurate predictions over a period of 1 month. The calibration was robust when faced with adjustment of reference cell intensity and did not require a daily measured reference spectrum. The root-mean-square error of prediction of urea was 0.4 mM based on a two-factor partial least-squares regression model.
© (2004) Society of Photo-Optical Instrumentation Engineers (SPIE)
Peter Snoer Jensen, Jimmy Bak, Soren Ladefoged, Stefan Andersson-Engels, Lennart Friis-Hansen, "Online monitoring of urea concentration in dialysate with dual-beam Fourier-transform near-infrared spectroscopy," Journal of Biomedical Optics 9(3), (1 May 2004). https://doi.org/10.1117/1.1689337 . Submission:
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