Optical coherence tomography of malignancy in hamster cheek pouches

Erin S. Matheny; Nevine M. Hanna; Reza Mina-Araghi; Woong Gyu Jung; Zhongping Chen; Petra B. B. Wilder-Smith; Matthew Brenner

doi:10.1117/1.1783897

1 September 2004 Optical coherence tomography of malignancy in hamster cheek pouches

Erin S. Matheny; Nevine M. Hanna; Reza Mina-Araghi; Woong Gyu Jung; Zhongping Chen; Petra B. B. Wilder-Smith; Matthew Brenner

Author Affiliations +

J. of Biomedical Optics, 9(5), (2004). https://doi.org/10.1117/1.1783897

Abstract

Optical coherence tomography (OCT)/optical Doppler tomography (ODT) provides real-time in vivo high-resolution (10-μm) imaging of tissues and real-time spatially resolved blood flow in microvasculature. Hamster cheek pouches with induced dysplasia and malignancies were imaged with OCT/ODT to assess the potential for application to airway malignancy. In 22 Golden Syrian hamsters, 0.5% 9,10-dimethyl-1,2-benzanthracene induces carcinogenesis over 10 weeks in right side cheek pouches; the left side three served as controls. The cheek pouches are imaged in vivo prior to sacrifice, and in vitro after excision, using a prototype 1310-nm broadband superluminescent diode based OCT/ODT device. Images are compared to standard histopathology. OCT imaging offers good resolution of the hamster cheek pouches to depths of 1 to 3 mm and paralleled histologic images. The feasibility of high-resolution functional imaging is demonstrated in this hamster cheek pouch tumor model. ODT accurately detects vascular change associated with carcinogenesis.

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Erin S. Matheny, Erin S. Matheny, Nevine M. Hanna, Nevine M. Hanna, Reza Mina-Araghi, Reza Mina-Araghi, Woong Gyu Jung, Woong Gyu Jung, Zhongping Chen, Zhongping Chen, Petra B. B. Wilder-Smith, Petra B. B. Wilder-Smith, Matthew Brenner, Matthew Brenner, } "Optical coherence tomography of malignancy in hamster cheek pouches," Journal of Biomedical Optics 9(5), (1 September 2004). https://doi.org/10.1117/1.1783897 . Submission:

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