1 September 2004 Three-dimensional optical tomographic brain imaging in small animals, part 2: Unilateral carotid occlusion
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Abstract
This is the second part of a two-part study that explores the feasibility of 3-D, volumetric brain imaging in small animals by optical tomographic techniques. In part 1, we demonstrated the ability to visualize global hemodynamic changes in the rat head in response to elevated levels of CO2 using a continuous-wave instrument and model-based iterative image reconstruction (MOBIIR) algorithm. Now we focus on lateralized, monohemispherically localized hemodynamic effects generated by unilateral common carotid artery (CCA) occlusion. This illustrates the capability of our optical tomographic system to localize and distinguish hemodynamic responses in different parts of the brain. Unilateral carotid occlusions are performed in ten rodents under two experimental conditions. In the first set of experiments the normal systemic blood pressure is lowered to 50 mmHg, and on unilateral carotid occlusion, we observe an ipsilateral monohemispheric global decrease in blood volume and oxygenation. This finding is consistent with the known physiologic response to cerebral ischemia. In a second set of experiments designed to observe the spatial-temporal dynamics of CCA occlusion at normotensive blood pressure, more complex phenomena are observed. We find three different types of responses, which can be categorized as compensation, overcompensation, and noncompensation.
© (2004) Society of Photo-Optical Instrumentation Engineers (SPIE)
Avraham Y. Bluestone, Avraham Y. Bluestone, Mark Stewart, Mark Stewart, B. Lei, B. Lei, I. S. Kass, I. S. Kass, Joseph M. Lasker, Joseph M. Lasker, Gassan S. Abdoulaev, Gassan S. Abdoulaev, Andreas H. Hielscher, Andreas H. Hielscher, } "Three-dimensional optical tomographic brain imaging in small animals, part 2: Unilateral carotid occlusion," Journal of Biomedical Optics 9(5), (1 September 2004). https://doi.org/10.1117/1.1784472 . Submission:
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