1 July 2010 Novel image analysis method for in situ monitoring the particle size distribution of batch crystallization processes
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Abstract
This article presents a new in situ method to monitor the particle size distribution (PSD) during batch solution crystallization processes. Using a new in situ imaging probe, the "EZProbe sensor," real time acquisition of 2-D images of particles during the batch process is now possible. To analyze these images, a novel image analysis method is carried out. First, segmentation and restoration algorithms are performed to identify the particles and thereafter geometrical particle measurements are achieved to obtained the PSD of the batch crystallization process over time. Satisfactory measurements are obtained provided that the overall solid concentration does not exceed a threshold above which too many overlapping crystals make discrimination between particles impossible.
© (2010) Society of Photo-Optical Instrumentation Engineers (SPIE)
Benoit Presles, Benoit Presles, Johan Debayle, Johan Debayle, Gilles Fevotte, Gilles Fevotte, Jean-Charles Pinoli, Jean-Charles Pinoli, } "Novel image analysis method for in situ monitoring the particle size distribution of batch crystallization processes," Journal of Electronic Imaging 19(3), 031207 (1 July 2010). https://doi.org/10.1117/1.3462800 . Submission:
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