Super-resolution-based magnification of endothelium cells from biomicroscope videos of the cornea

Dario Comanducci; Fabio Bellavia; Carlo Colombo

doi:10.1117/1.JEI.27.4.043029

30 July 2018 Super-resolution-based magnification of endothelium cells from biomicroscope videos of the cornea

Dario Comanducci, Fabio Bellavia, Carlo Colombo

Author Affiliations +

Journal of Electronic Imaging, Vol. 27, Issue 4, 043029 (July 2018). https://doi.org/10.1117/1.JEI.27.4.043029

Abstract

We present a practical, robust, and effective pipeline to compute a high-resolution (HR) image of the corneal endothelium starting from a low-resolution (LR) video sequence obtained with a general purpose slit lamp biomicroscope. An image quality typical of dedicated and more expensive confocal microscopes is achieved via software magnification by exploiting information redundancy in the video sequence. In particular, the HR image is generated from the best LR frames, obtained by identifying the most suitable endothelium video subsequence using a support vector machine-based learning approach, followed by a robust graph-based frame registration. Results on long, real sequences show that the proposed approach is fast and produces better quality images than both classical multiframe super-resolution approaches and commercial state-of-the-art mosaicing software. Only low-cost equipment is required that makes the proposed method a valid diagnostic tool and an affordable resource for medical practice in both developed and developing countries.

Citation Download Citation

Dario Comanducci, Fabio Bellavia, and Carlo Colombo "Super-resolution-based magnification of endothelium cells from biomicroscope videos of the cornea," Journal of Electronic Imaging 27(4), 043029 (30 July 2018). https://doi.org/10.1117/1.JEI.27.4.043029

Received: 2 February 2018; Accepted: 12 July 2018; Published: 30 July 2018

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