22 November 2016 Initial performance studies of a wearable brain positron emission tomography camera based on autonomous thin-film digital Geiger avalanche photodiode arrays
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Abstract
Using analytical and Monte Carlo modeling, we explored performance of a lightweight wearable helmet-shaped brain positron emission tomography (PET), or BET camera, based on thin-film digital Geiger avalanche photodiode arrays with Lutetium-yttrium oxyorthosilicate (LYSO) or LaBr3 scintillators for imaging in vivo human brain function of freely moving and acting subjects. We investigated a spherical cap BET and cylindrical brain PET (CYL) geometries with 250-mm diameter. We also considered a clinical whole-body (WB) LYSO PET/CT scanner. The simulated energy resolutions were 10.8% (LYSO) and 3.3% (LaBr3), and the coincidence window was set at 2 ns. The brain was simulated as a water sphere of uniform F-18 activity with a radius of 100 mm. We found that BET achieved >40% better noise equivalent count (NEC) performance relative to the CYL and >800% than WB. For 10-mm-thick LaBr3 equivalent mass systems, LYSO (7-mm thick) had ∼40% higher NEC than LaBr3. We found that 1×1×3  mm scintillator crystals achieved ∼1.1  mm full-width-half-maximum spatial resolution without parallax errors. Additionally, our simulations showed that LYSO generally outperformed LaBr3 for NEC unless the timing resolution for LaBr3 was considerably smaller than that presently used for LYSO, i.e., well below 300 ps.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Charles R. Schmidtlein, James N. Turner, Michael O. Thompson, Krishna C. Mandal, Ida Häggström, Jiahan Zhang, John L. Humm, David H. Feiglin, Andrzej Krol, "Initial performance studies of a wearable brain positron emission tomography camera based on autonomous thin-film digital Geiger avalanche photodiode arrays," Journal of Medical Imaging 4(1), 011003 (22 November 2016). https://doi.org/10.1117/1.JMI.4.1.011003 . Submission:
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