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29 May 2020 Automated mammographic density measurement using Quantra™: comparison with the Royal Australian and New Zealand College of Radiology synoptic scale
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Abstract

Purpose: This technology evaluation study assesses the limits of agreement between the mammographic density (MD) measurement of Quantra™ from different breasts and mammographic views and its agreement with the Royal Australian and New Zealand College of Radiologists (RANZCR) synoptic scale.

Approach: MD of 800 women was assessed by Quantra™ and seven radiologists using the RANZCR synoptic scale. Bland–Altman analysis was used to assess the limits of agreement between Quantra™ MD measures from both breasts and mammographic views. The agreement between Quantra™ and the RANZCR synoptic scale was assessed using weighted kappa (Kw). The receiver operating characteristics area under the curve (AUC) was used to assess the performance of Quantra™ in reproducing RANZCR MD ratings.

Results: There was no significant bias in the mean MD of Quantra™ from both breasts: left versus right craniocaudal (CC) views (B  =    −  0.14; p  =  0.36) and right versus left mediolateral oblique (MLO) (B  =    −  0.021; p  =  0.18). However, MD measures from the same breast but different views showed significant bias: right CC versus right MLO (B  =  0.064; p  <  0.0001) and left CC versus left MLO (B  =  0.56; p  <  0.0001). Quantra™ demonstrated substantial agreement with the RANZCR synoptic scale on four- and two-category scales (Kw  =  0.62; 0.59 to 0.66 and 0.76; 0.72 to 0.81, respectively). Quantra™ better reproduced the RANZCR synoptic scale on a two-category scale (AUC  =  0.88; 0.84 to 0.91) than a four-category scale (AUC  =  0.62; 0.58 to 0.67 to 0.78; 0.74 to 0.82).

Conclusions: Quantra™ reproduces MD classification using the RANZCR synoptic scale on a two-category scale and should help in identification of women with dense breasts who may need adjunctive imaging for early detection of breast cancer.

© 2020 Society of Photo-Optical Instrumentation Engineers (SPIE) 2329-4302/2020/$28.00 © 2020 SPIE
Inez Yeo, Judith Akwo, and Ernest U. Ekpo "Automated mammographic density measurement using Quantra™: comparison with the Royal Australian and New Zealand College of Radiology synoptic scale," Journal of Medical Imaging 7(3), 035501 (29 May 2020). https://doi.org/10.1117/1.JMI.7.3.035501
Received: 11 February 2020; Accepted: 19 May 2020; Published: 29 May 2020
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