A 1500-µm-diam silicon/silicon nitride 3-D scan mirror has been built using MOEMS technology. It is capable of static and dynamic beam scanning achieved with a biaxial gimbal. A gold-coated deformable membrane at the center of the device provides both focus control (z axis) and spherical aberration correction. This architecture is able to move the focus of a laser beam throughout a 3-D space with one single optical surface, and is referred to as a MOEMS 3-D scan mirror. This mirror will be incorporated into a miniature confocal laser scanning microscope for biomedical in-situ imaging applications. We describe the 3-D scan mirror design, fabrication, characterization, and briefly describe the target application. A confocal laser scanning microscope using this mirror to achieve beam scanning and focus control is also demonstrated.