Book Review: Review of a viral peptide nanosystem for intracellular delivery

Annarita Falanga; Rossella Tarallo; Emilia Galdiero; Marco Cantisani; Massimiliano Galdiero; Stefania Galdiero

doi:10.1117/1.JNP.7.071599

16 January 2013 Review of a viral peptide nanosystem for intracellular delivery

Annarita Falanga, Rossella Tarallo, Emilia Galdiero, Marco Cantisani, Massimiliano Galdiero, Stefania Galdiero

Author Affiliations +

Journal of Nanophotonics, Vol. 7, Issue 1, 071599 (January 2013). https://doi.org/10.1117/1.JNP.7.071599

Abstract

The internalization of bioactive molecules is one of the most critical problems to overcome in theranostics. In order to improve pharmacokinetic and pharmacodynamic properties, synthetic transporters are widely investigated. A new nanotechnological transporter, gH625, is based on a viral peptide sequence derived from the herpes simplex virus type 1 glycoprotein H (gH) that has proved to be a useful delivery vehicle, due to its intrinsic properties of inducing membrane perturbation. The peptide functionalization with several kinds of nanoparticles like quantum dots, dendrimers, and liposomes could be of particular interest in biomedical applications to improve drug release within cells, to increase site-specific action, and eventually to reduce related cytotoxicity.

© The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Annarita Falanga, Rossella Tarallo, Emilia Galdiero, Marco Cantisani, Massimiliano Galdiero, and Stefania Galdiero "Review of a viral peptide nanosystem for intracellular delivery," Journal of Nanophotonics 7(1), 071599 (16 January 2013). https://doi.org/10.1117/1.JNP.7.071599

Published: 16 January 2013

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KEYWORDS

Dendrimers

Nanoparticles

Molecules

Toxicity

Blood brain barrier

In vitro testing

Brain

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