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28 July 2014 Alternating current and infrared produce an onset-free reversible nerve block
Emilie H. Lothet, Kevin L. Kilgore, Niloy Bhadra, Narendra Bhadra, Tina Vrabec, Yves T. Wang, E. Duco Jansen, Michael W. Jenkins, Hillel J. Chiel
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Neurophotonics, Vol. 1, Issue 1, 011010 (July 2014). https://doi.org/10.1117/1.NPh.1.1.011010
Abstract
Nerve block can eliminate spasms and chronic pain. Kilohertz frequency alternating current (KHFAC) produces a safe and reversible nerve block. However, KHFAC-induced nerve block is associated with an undesirable onset response. Optical inhibition using infrared (IR) laser light can produce nerve block without an onset response, but heats nerves. Combining KHFAC with IR inhibition [alternating current and infrared (ACIR)] produces a rapidly reversible nerve block without an onset response. ACIR can be used to rapidly and reversibly provide onset-free nerve block in the unmyelinated nerves of the marine mollusk Aplysia californica and may have significant advantages over either modality alone. ACIR may be of great clinical utility in the future.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Emilie H. Lothet, Kevin L. Kilgore, Niloy Bhadra, Narendra Bhadra, Tina Vrabec, Yves T. Wang, E. Duco Jansen, Michael W. Jenkins, and Hillel J. Chiel "Alternating current and infrared produce an onset-free reversible nerve block," Neurophotonics 1(1), 011010 (28 July 2014). https://doi.org/10.1117/1.NPh.1.1.011010
Published: 28 July 2014
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Cited by 31 scholarly publications and 5 patents.
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KEYWORDS
Nerve
Electrodes
Infrared radiation
Ocean optics
Infrared lasers
Optical fibers
Action potentials
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