4 August 2015 Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts
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We introduce and validate a pressure measurement paradigm that reduces extracerebral contamination from superficial tissues in optical monitoring of cerebral blood flow with diffuse correlation spectroscopy (DCS). The scheme determines subject-specific contributions of extracerebral and cerebral tissues to the DCS signal by utilizing probe pressure modulation to induce variations in extracerebral blood flow. For analysis, the head is modeled as a two-layer medium and is probed with long and short source-detector separations. Then a combination of pressure modulation and a modified Beer-Lambert law for flow enables experimenters to linearly relate differential DCS signals to cerebral and extracerebral blood flow variation without
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
Wesley B. Baker, Wesley B. Baker, Ashwin B. Parthasarathy, Ashwin B. Parthasarathy, Tiffany S. Ko, Tiffany S. Ko, David R. Busch, David R. Busch, Kenneth Abramson, Kenneth Abramson, Shih-Yu Tzeng, Shih-Yu Tzeng, Rickson C. Mesquita, Rickson C. Mesquita, Turgut Durduran, Turgut Durduran, Joel H. Greenberg, Joel H. Greenberg, David K. Kung, David K. Kung, Arjun G. Yodh, Arjun G. Yodh, } "Pressure modulation algorithm to separate cerebral hemodynamic signals from extracerebral artifacts," Neurophotonics 2(3), 035004 (4 August 2015). https://doi.org/10.1117/1.NPh.2.3.035004 . Submission:

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