2 May 2016 Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy
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Abstract
Burst suppression (BS) is an electroencephalographic state associated with a profound inactivation of the brain. BS and pathological discontinuous electroencephalography (EEG) are often observed in term-age infants with neurological injury and can be indicative of a poor outcome and lifelong disability. Little is known about the neurophysiological mechanisms of BS or how the condition relates to the functional state of the neonatal brain. We used simultaneous EEG and diffuse optical tomography (DOT) to investigate whether bursts of EEG activity in infants with hypoxic ischemic encephalopathy are associated with an observable cerebral hemodynamic response. We were able to identify significant changes in concentration of both oxy and deoxyhemoglobin that are temporally correlated with EEG bursts and present a relatively consistent morphology across six infants. Furthermore, DOT reveals patient-specific spatial distributions of this hemodynamic response that may be indicative of a complex pattern of cortical activation underlying discontinuous EEG activity that is not readily apparent in scalp EEG.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Maria Chalia, Maria Chalia, Chuen Wai Lee, Chuen Wai Lee, Laura A. Dempsey, Laura A. Dempsey, Andrea D. Edwards, Andrea D. Edwards, Harsimrat Singh, Harsimrat Singh, Andrew W. Michell, Andrew W. Michell, Nicholas L. Everdell, Nicholas L. Everdell, Reuben W. Hill, Reuben W. Hill, Jeremy C. Hebden, Jeremy C. Hebden, Topun Austin, Topun Austin, Robert J. Cooper, Robert J. Cooper, } "Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy," Neurophotonics 3(3), 031408 (2 May 2016). https://doi.org/10.1117/1.NPh.3.3.031408 . Submission:
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