12 October 2016 Intraoperative video-rate hemodynamic response assessment in human cortex using snapshot hyperspectral optical imaging
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Abstract
Using light, we are able to visualize the hemodynamic behavior of the brain to better understand neurovascular coupling and cerebral metabolism. In vivo optical imaging of tissue using endogenous chromophores necessitates spectroscopic detection to ensure molecular specificity as well as sufficiently high imaging speed and signal-to-noise ratio, to allow dynamic physiological changes to be captured, isolated, and used as surrogate of pathophysiological processes. An optical imaging system is introduced using a 16-bands on-chip hyperspectral camera. Using this system, we show that up to three dyes can be imaged and quantified in a tissue phantom at video-rate through the optics of a surgical microscope. In vivo human patient data are presented demonstrating brain hemodynamic response can be measured intraoperatively with molecular specificity at high speed.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE)
Julien Pichette, Audrey Laurence, Leticia Angulo, Frederic Lesage, Alain Bouthillier, Dang Khoa Nguyen, Frédéric Leblond, "Intraoperative video-rate hemodynamic response assessment in human cortex using snapshot hyperspectral optical imaging," Neurophotonics 3(4), 045003 (12 October 2016). https://doi.org/10.1117/1.NPh.3.4.045003 . Submission:
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