12 January 2017 Fluorescence-guided resection of brain tumor: review of the significance of intraoperative quantification of protoporphyrin IX fluorescence
Author Affiliations +
Neurophotonics, 4(1), 011011 (2017). doi:10.1117/1.NPh.4.1.011011
Abstract
Surgical removal of tumor mass is a common approach in the management of brain tumors. However, the precise delineation of normal tissue from tumor tissue for a complete resection of tumor mass in brain tumor surgery remains a difficult task for neurosurgeons. Aminolevulinic acid (ALA)-mediated exgogenous fluorescence of protoporphyrin IX (PpIX) is a sensitive approach for tumor imaging. Recent studies suggest that the use of ALA/PpIX-mediated fluorescence-guided resection (FGR) or fluorescence-guided surgery can enable more accurate and complete resection of brain tumors, especially when used in quantitative fashion. This review will highlight the current progress in PpIX-mediated FGR and discuss technical challenges in intraoperative quantification of intracellular PpIX fluorescence during FGR of brain tumor.
Zheng Huang, Haixia Qiu, Songsheng Shi, Desheng Li, Jian Zou, Shaoshan Hu, "Fluorescence-guided resection of brain tumor: review of the significance of intraoperative quantification of protoporphyrin IX fluorescence," Neurophotonics 4(1), 011011 (12 January 2017). http://dx.doi.org/10.1117/1.NPh.4.1.011011
Submission: Received 1 July 2016; Accepted 20 December 2016
JOURNAL ARTICLE
5 PAGES


SHARE
KEYWORDS
Tumors

Luminescence

Brain

Tissues

Tissue optics

In vivo imaging

Fluorescence spectroscopy

Back to Top