4 May 2017 Mammalian cortical voltage imaging using genetically encoded voltage indicators: a review honoring professor Amiram Grinvald
Author Affiliations +
Neurophotonics, 4(3), 031214 (2017). doi:10.1117/1.NPh.4.3.031214
Abstract
The pioneering work of Amiram Grinvald established voltage-sensitive dye imaging (VSDI) in the mammalian cortex in the 1980s and inspired decades of cortical voltage imaging and the associated technological developments. The recent conception and development of genetically encoded voltage indicators (GEVIs) overcome many of the limitations of classical VSDI, and open experimental approaches that provide accruing support for orchestrated neuronal circuit dynamics of spatially distributed neuronal circuit underlying behaviors. We will review recent achievements using GEVIs to optically monitor the cortical activity in mammalian brains in vivo and provide a perspective for potential future directions.
Chenchen Song, Samuel J. Barnes, Thomas Knöpfel, "Mammalian cortical voltage imaging using genetically encoded voltage indicators: a review honoring professor Amiram Grinvald," Neurophotonics 4(3), 031214 (4 May 2017). http://dx.doi.org/10.1117/1.NPh.4.3.031214
Submission: Received 17 January 2017; Accepted 5 April 2017
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KEYWORDS
Sensors

Brain

In vivo imaging

Neurons

Sensory processes

Luminescence

Calcium

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