11 March 2017 Spatial landscape of oxygen in and around microvasculature during epileptic events
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Abstract
Measuring changes in cerebral oxygen in tissue microdomains during epilepsy is important to identify hypoxic potential. Here, using a custom-built two-photon microscopy system, we present microscopic measurements of oxygen partial pressure ( PO 2 ) in cortical microvessels and tissue of anesthetized mice during 4-aminopyridine (4-AP)-induced epileptic seizures. Investigating epileptic events, we characterized the distribution of the “initial dip” in PO 2 in arterioles, venules, and tissue near the 4-AP injection site. Our results reveal a correlation between the percent change in PO 2 during the “initial dip” and the diameter of nearest arterioles and venules.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Cong Zhang, Cong Zhang, Mohammad Moeini, Mohammad Moeini, Frédéric Lesage, Frédéric Lesage, } "Spatial landscape of oxygen in and around microvasculature during epileptic events," Neurophotonics 4(1), 010501 (11 March 2017). https://doi.org/10.1117/1.NPh.4.1.010501 . Submission: Received: 31 October 2016; Accepted: 17 February 2017
Received: 31 October 2016; Accepted: 17 February 2017; Published: 11 March 2017
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