Fluorescence-guided resection of brain tumor: review of the significance of intraoperative quantification of protoporphyrin IX fluorescence

Zheng Huang; Haixia Qiu; Songsheng Shi; Desheng Li; Jian Zou; Shaoshan Hu

doi:10.1117/1.NPh.4.1.011011

12 January 2017 Fluorescence-guided resection of brain tumor: review of the significance of intraoperative quantification of protoporphyrin IX fluorescence

Zheng Huang, Haixia Qiu, Songsheng Shi, Desheng Li, Jian Zou, Shaoshan Hu

Author Affiliations +

Neurophotonics, Vol. 4, Issue 1, 011011 (January 2017). https://doi.org/10.1117/1.NPh.4.1.011011

Abstract

Surgical removal of tumor mass is a common approach in the management of brain tumors. However, the precise delineation of normal tissue from tumor tissue for a complete resection of tumor mass in brain tumor surgery remains a difficult task for neurosurgeons. Aminolevulinic acid (ALA)-mediated exgogenous fluorescence of protoporphyrin IX (PpIX) is a sensitive approach for tumor imaging. Recent studies suggest that the use of ALA/PpIX-mediated fluorescence-guided resection (FGR) or fluorescence-guided surgery can enable more accurate and complete resection of brain tumors, especially when used in quantitative fashion. This review will highlight the current progress in PpIX-mediated FGR and discuss technical challenges in intraoperative quantification of intracellular PpIX fluorescence during FGR of brain tumor.

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Zheng Huang, Haixia Qiu, Songsheng Shi, Desheng Li, Jian Zou, and Shaoshan Hu "Fluorescence-guided resection of brain tumor: review of the significance of intraoperative quantification of protoporphyrin IX fluorescence," Neurophotonics 4(1), 011011 (12 January 2017). https://doi.org/10.1117/1.NPh.4.1.011011

Received: 1 July 2016; Accepted: 20 December 2016; Published: 12 January 2017

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KEYWORDS

Tumors

Luminescence

Brain

Tissues

Tissue optics

Fluorescence spectroscopy

In vivo imaging

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