18 April 2017 Relationship between relative cerebral blood flow, relative cerebral blood volume, and relative cerebral metabolic rate of oxygen in the preterm neonatal brain
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Abstract
The mechanisms responsible for coupling between relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), and relative cerebral metabolic rate of oxygen ( rCMRO 2 ), an important function of the microcirculation in preterm infants, remain unclear. Identification of a causal relationship between rCBF–rCBV and rCBF rCMRO 2 in preterms may, therefore, help to elucidate the principles of cortical hemodynamics during development. We simultaneously recorded rCBF and rCBV and estimated rCMRO 2 by two independent acquisition systems: diffuse correlation spectroscopy and near-infrared spectroscopy, respectively, in 10 preterms aged between 28 and 35 weeks of gestational age. Transfer entropy was calculated in order to determine the directionality between rCBF–rCBV and rCBF rCMRO 2 . The surrogate method was applied to determine statistical significance. The results show that rCBV and rCMRO 2 have a predominant driving influence on rCBF at the resting state in the preterm neonatal brain. Statistical analysis robustly detected the correct directionality of rCBV on rCBF and rCMRO 2 on rCBF. This study helps to clarify the early organization of the rCBV–rCBF and rCBF rCMRO 2 inter-relationship in the immature cortex.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Mina Nourhashemi, Guy Kongolo, Mahdi Mahmoudzadeh, Sabrina Goudjil, Fabrice Wallois, "Relationship between relative cerebral blood flow, relative cerebral blood volume, and relative cerebral metabolic rate of oxygen in the preterm neonatal brain," Neurophotonics 4(2), 021104 (18 April 2017). https://doi.org/10.1117/1.NPh.4.2.021104 . Submission: Received: 13 January 2017; Accepted: 30 March 2017
Received: 13 January 2017; Accepted: 30 March 2017; Published: 18 April 2017
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