18 April 2017 Relationship between relative cerebral blood flow, relative cerebral blood volume, and relative cerebral metabolic rate of oxygen in the preterm neonatal brain
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Abstract
The mechanisms responsible for coupling between relative cerebral blood flow (rCBF), relative cerebral blood volume (rCBV), and relative cerebral metabolic rate of oxygen ( rCMRO 2 ), an important function of the microcirculation in preterm infants, remain unclear. Identification of a causal relationship between rCBF–rCBV and rCBF rCMRO 2 in preterms may, therefore, help to elucidate the principles of cortical hemodynamics during development. We simultaneously recorded rCBF and rCBV and estimated rCMRO 2 by two independent acquisition systems: diffuse correlation spectroscopy and near-infrared spectroscopy, respectively, in 10 preterms aged between 28 and 35 weeks of gestational age. Transfer entropy was calculated in order to determine the directionality between rCBF–rCBV and rCBF rCMRO 2 . The surrogate method was applied to determine statistical significance. The results show that rCBV and rCMRO 2 have a predominant driving influence on rCBF at the resting state in the preterm neonatal brain. Statistical analysis robustly detected the correct directionality of rCBV on rCBF and rCMRO 2 on rCBF. This study helps to clarify the early organization of the rCBV–rCBF and rCBF rCMRO 2 inter-relationship in the immature cortex.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Mina Nourhashemi, Mina Nourhashemi, Guy Kongolo, Guy Kongolo, Mahdi Mahmoudzadeh, Mahdi Mahmoudzadeh, Sabrina Goudjil, Sabrina Goudjil, Fabrice Wallois, Fabrice Wallois, } "Relationship between relative cerebral blood flow, relative cerebral blood volume, and relative cerebral metabolic rate of oxygen in the preterm neonatal brain," Neurophotonics 4(2), 021104 (18 April 2017). https://doi.org/10.1117/1.NPh.4.2.021104 . Submission: Received: 13 January 2017; Accepted: 30 March 2017
Received: 13 January 2017; Accepted: 30 March 2017; Published: 18 April 2017
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