Image reconstruction of oxidized cerebral cytochrome C oxidase changes from broadband near-infrared spectroscopy data

Sabrina Brigadoi; Phong Phan; David Highton; Samuel Powell; Robert J. Cooper; Jeremy C. Hebden; Martin Smith; Ilias Tachtsidis; Clare E. Elwell; Adam P. Gibson

doi:10.1117/1.NPh.4.2.021105

24 May 2017 Image reconstruction of oxidized cerebral cytochrome C oxidase changes from broadband near-infrared spectroscopy data

Sabrina Brigadoi, Phong Phan, David Highton, Samuel Powell, Robert J. Cooper, Jeremy C. Hebden, Martin Smith, Ilias Tachtsidis, Clare E. Elwell, Adam P. Gibson

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Neurophotonics, Vol. 4, Issue 2, 021105 (May 2017). https://doi.org/10.1117/1.NPh.4.2.021105

Abstract

In diffuse optical tomography (DOT), overlapping and multidistance measurements are required to reconstruct depth-resolved images of oxy- (HbO2) and deoxy- (HHb) hemoglobin concentration changes occurring in the brain. These can be considered an indirect measure of brain activity, under the assumption of intact neurovascular coupling. Broadband systems also allow changes in the redox state of cytochrome c oxidase (oxCCO) to be measured, which can be an important biomarker when neurovascular coupling is impaired. We used DOT to reconstruct images of Δ[HbO2], Δ[HHb], and Δ[oxCCO] from data acquired with a broadband system. Four healthy volunteers were measured while performing a visual stimulation task (4-Hz inverting checkerboard). The broadband system was configured to allow multidistance and overlapping measurements of the participants’ visual cortex with 32 channels. A multispectral approach was employed to reconstruct changes in concentration of the three chromophores during the visual stimulation. A clear and focused activation was reconstructed in the left occipital cortex of all participants. The difference between the residuals of the three-chromophore model and of the two-chromophore model (recovering only Δ[HbO2] and Δ[HHb]) exhibits a spectrum similar to that of oxCCO. These results form a basis for further studies aimed to further optimize image reconstruction of Δ[oxCCO].

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Sabrina Brigadoi, Phong Phan, David Highton, Samuel Powell, Robert J. Cooper, Jeremy C. Hebden, Martin Smith, Ilias Tachtsidis, Clare E. Elwell, and Adam P. Gibson "Image reconstruction of oxidized cerebral cytochrome C oxidase changes from broadband near-infrared spectroscopy data," Neurophotonics 4(2), 021105 (24 May 2017). https://doi.org/10.1117/1.NPh.4.2.021105

Received: 3 March 2017; Accepted: 1 May 2017; Published: 24 May 2017

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