In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy

Lorenzo Spinelli; Lucia Zucchelli; Davide Contini; Matteo Caffini; Jacques Mehler; Ana Fló; Alissa L. Ferry; Luca Filippin; Francesco Macagno; Luigi Cattarossi; Alessandro Torricelli

doi:10.1117/1.NPh.4.4.041414

18 August 2017 In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy

Lorenzo Spinelli, Lucia Zucchelli, Davide Contini, Matteo Caffini, Jacques Mehler, Ana Fló, Alissa L. Ferry, Luca Filippin, Francesco Macagno, Luigi Cattarossi, Alessandro Torricelli

Author Affiliations +

Neurophotonics, Vol. 4, Issue 4, 041414 (August 2017). https://doi.org/10.1117/1.NPh.4.4.041414

Abstract

By exploiting a multichannel portable instrument for time-domain near-infrared spectroscopy (TD-NIRS), we characterized healthy neonates’ brains in term of optical properties and hemodynamic parameters. In particular, we assessed the absolute values of the absorption and reduced scattering coefficients at two wavelengths, together with oxy-, deoxy- and total hemoglobin concentrations, and the blood oxygen saturation of the neonates’ brains. In this study, 33 healthy full-term neonates were tested, obtaining the following median values: 0.28 and 0.31 cm−1 for μa at 690 and 820 nm, respectively; 5.8 and 5.3 cm−1 for μs′ at 690 and 820 nm, respectively; 103 μM for cO2Hb; 42.6 μM for cHHb; 146 μM for ctHb; 72% for sO2. In general, the agreement of these values with the sparse existing literature appears not always consistent. These findings demonstrate the first measurements of optical properties of the healthy neonate brain using TD-NIRS and show the need for clarification of optical properties across methods and populations.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Lorenzo Spinelli, Lucia Zucchelli, Davide Contini, Matteo Caffini, Jacques Mehler, Ana Fló, Alissa L. Ferry, Luca Filippin, Francesco Macagno, Luigi Cattarossi, and Alessandro Torricelli "In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy," Neurophotonics 4(4), 041414 (18 August 2017). https://doi.org/10.1117/1.NPh.4.4.041414

Received: 30 March 2017; Accepted: 11 July 2017; Published: 18 August 2017

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