4 October 2017 Integrated treatment modality of cathodal-transcranial direct current stimulation with peripheral sensory stimulation affords neuroprotection in a rat stroke model
Author Affiliations +
Neurophotonics, 4(4), 045002 (2017). doi:10.1117/1.NPh.4.4.045002
Abstract
Cathodal-transcranial direct current stimulation induces therapeutic effects in animal ischemia models by preventing the expansion of ischemic injury during the hyperacute phase of ischemia. However, its efficacy is limited by an accompanying decrease in cerebral blood flow. On the other hand, peripheral sensory stimulation can increase blood flow to specific brain areas resulting in rescue of neurovascular functions from ischemic damage. Therefore, the two modalities appear to complement each other to form an integrated treatment modality. Our results showed that hemodynamics was improved in a photothrombotic ischemia model, as cerebral blood volume and hemoglobin oxygen saturation (
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Yu-Hang Liu, Su Jing Chan, Han-Chi Pan, Aishwarya Bandla, Nicolas K. K. King, Peter Tsun Hon Wong, You-Yin Chen, Wai Hoe Ng, Nitish V. Thakor, Lun-De Liao, "Integrated treatment modality of cathodal-transcranial direct current stimulation with peripheral sensory stimulation affords neuroprotection in a rat stroke model," Neurophotonics 4(4), 045002 (4 October 2017). http://dx.doi.org/10.1117/1.NPh.4.4.045002 Submission: Received 7 July 2017; Accepted 12 September 2017
Submission: Received 7 July 2017; Accepted 12 September 2017
JOURNAL ARTICLE
13 PAGES


SHARE
KEYWORDS
Ischemia

Hemodynamics

Electrodes

Brain

Blood vessels

Sensors

Blood

Back to Top