Non-neuronal evoked and spontaneous hemodynamic changes in the anterior temporal region of the human head may lead to misinterpretations of functional near-infrared spectroscopy signals

Guilherme Agusto Zimeo Morais; Felix Scholkmann; Joana Bisol Balardin; Rogério Akira Furucho; Renan Costa Vieira de Paula; Claudinei Eduardo Biazoli; João Ricardo Sato

doi:10.1117/1.NPh.5.1.011002

22 August 2017 Non-neuronal evoked and spontaneous hemodynamic changes in the anterior temporal region of the human head may lead to misinterpretations of functional near-infrared spectroscopy signals

Guilherme Agusto Zimeo Morais, Felix Scholkmann, Joana Bisol Balardin, Rogério Akira Furucho, Renan Costa Vieira de Paula, Claudinei Eduardo Biazoli, João Ricardo Sato

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Neurophotonics, Vol. 5, Issue 1, 011002 (August 2017). https://doi.org/10.1117/1.NPh.5.1.011002

Abstract

Several functional near-infrared spectroscopy (fNIRS) studies report their findings based on changes of a single chromophore, usually concentration changes of oxygenated hemoglobin ([O2Hb]) or deoxygenated hemoglobin (HHb). However, influence of physiological actions may differ depending on which element is considered and the assumption that the chosen measure correlates with the neural response of interest might not hold. By assessing the correlation between [O2Hb] and [HHb] in task-evoked activity as well as resting-state data, we identified a spatial dependency of non-neuronal hemodynamic changes in the anterior temporal region of the human head. Our findings support the importance of reporting and discussing fNIRS outcomes obtained with both chromophores ([O2Hb] and [HHb]), in particular, for studies concerning the anterior temporal region of the human head. This practice should help to achieve a physiologically correct interpretation of the results when no measurements with short-distance channels are available while employing continuous-wave fNIRS systems.

CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Guilherme Agusto Zimeo Morais, Felix Scholkmann, Joana Bisol Balardin, Rogério Akira Furucho, Renan Costa Vieira de Paula, Claudinei Eduardo Biazoli, and João Ricardo Sato "Non-neuronal evoked and spontaneous hemodynamic changes in the anterior temporal region of the human head may lead to misinterpretations of functional near-infrared spectroscopy signals," Neurophotonics 5(1), 011002 (22 August 2017). https://doi.org/10.1117/1.NPh.5.1.011002

Received: 24 March 2017; Accepted: 24 July 2017; Published: 22 August 2017

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