10 October 2017 Spatial variation in the hemoglobin phase of oxygenation and deoxygenation in the developing cortex of infants
Author Affiliations +
Abstract
Spontaneous low-frequency oscillatory changes in oxygenated hemoglobin (oxy-Hb) and deoxygenated hemoglobin (deoxy-Hb) are observed using functional near-infrared spectroscopy (fNIRS). A previous study showed that the time-averaged phase difference between oxy-Hb and deoxy-Hb changes, referred to as hemoglobin phase of oxygenation and deoxygenation (hPod), is sensitive to the development of the cortex. We examined phase-locking index of hPod, referred to as hPodL, in addition to hPod, in neonates and 3- and 6-month-old infants using the 94-channel fNIRS data, which covered large lateral regions of the cortex. The results showed that (1) developmental changes in hPod exhibited spatial dependency; (2) hPodL increased between the neonate group and 3-month-old infant group over the posterior, but not anterior, regions of the cortex; and (3) the cortical regions of each age group were clustered in several domains with specific characteristics of hPod and hPodL. This study indicates that the neonatal cortex is composed of regions with specific characteristics of hPod and hPodL, and drastic changes occur between the neonatal period and 3 months of age. This study suggests that hPod and hPodL are sensitive to the cortical region-specific development of the circulatory, blood flow, metabolic, and neurovascular functions in young infants.
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
Gentaro Taga, Hama Watanabe, Fumitaka Homae, "Spatial variation in the hemoglobin phase of oxygenation and deoxygenation in the developing cortex of infants," Neurophotonics 5(1), 011017 (10 October 2017). https://doi.org/10.1117/1.NPh.5.1.011017 . Submission: Received: 15 April 2017; Accepted: 18 September 2017
Received: 15 April 2017; Accepted: 18 September 2017; Published: 10 October 2017
JOURNAL ARTICLE
7 PAGES


SHARE
Back to Top